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pentobarbital will decrease the extent or result of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Solid or average CYP3A4 inducers may possibly raise rate of diazepam elimination; therefore, efficacy of diazepam may be diminished.pentobarbital will lessen the extent or outcome of buprenorphine by i